By Plane:
La Aurora International Airport (GUA) near Guatemala City is where most international flights depart and arrive. Grupo TACA has flights to Cancun, Chicago, Los Angeles, Mexico City, Miami, New York, San José in Costa Rica San Pedro Sula in Honduras San Salvador, Tegucigalpa and Washington. Several other destinations are mostly within Central America or the United States, but Iberia has direct flights to and from Madrid.
By Train:
There is no scheduled passenger train to and from Guatemala although there is a line to Mexico and one to El Salvador used by freight trains and chartered for tours as well.
By Car:
The Pan-American Highway runs through Guatemala from Mexico in the north and El Salvador in the south and even access from Belize via Flores is possible.
By Bus:
Tica Bus is a major operator in Central America, with connections to and from Guatemala from all neighbouring countries, including direct services from El Salvador. There are also buses to and from Mexico and Honduras, less so from Belize.
Travel times from Guatemala City are around 6 hours to San Salvador in El Salvador and San Pedro Sula in Honduras. There is only one land connection to Belize, just west of San Ignacio, on the road to Tikal/Flores.
By Boat:
There are ferries between Livingston and Puerto Barrios in Guatemala to several places in southern Belize, like Punta Gorda. Services from Puerto Barrios tend to be more frequent, with daily connections in both directions. Services from Livingston are mostly twice a week. There's also a boat from Lívingston to Omoa in Honduras, which usually goes daily.