By Plane:
Copa Airlines is the national carrier of Panama with its base at Tocumen International Airport (PTY) near the capital Panama City. It operates services to most major cities in Central and South America, including a few in the United States. Other destinations to and from Panama are Toronto, Montreal, Madrid and from March 2008 a direct flight from Amsterdam with KLM. Air Caraibes flies to Guadeloupe and Martinique. From Enrique Malek International Airport in David, there are international flights to and from San José in Costa Rica.
By Train:
There are no international rail links with Panama.
By Car:
Although Panama borders both Costa Rica and Colombia, only the first one can be reached by car along relatively good roads. Paso Canoas along the Panamerican highway is the most used crossing. Others include border crossings at Guabito-Sixaola near the Caribbean coast and Río Sereno at the terminus of the La Concepción Vacán road.
By Bus:
International bus connections are only possible to and from Costa Rica. Check Ticabus for options between Panama City and San José, Costa Rica.
By Boat:
The most popular boat connections travellers take is between Colón and Cartagena in Colombia. Although there is no regular scheduled boat services, cargo ships and yachts might take you or you can go on an organised trip, which usually stop in the San Blas Islands as well.